Adhesion G protein-coupled receptors have a large extracellular region (shown in green and orange) that extends into space outside the cell. Almost 35% of drugs approved by the Food and Drug ...

Blockbuster anti-obesity drugs like Ozempic and Wegovy have become household names in the past few years. They work by activating the glucagon-like peptide 1 receptor (GLP-1R) to stimulate insulin ...

Scientists at École Polytechnique Fédérale Lausanne (EPFL), and at UNIL-CHUV, University Hospital Lausanne (CHUV) and University of Lausanne (UNIL) have developed a computational method to create ...

This figure illustrates the odor sensor function of Pv11-00443-Or47a cell line. When pentyl acetate binds specifically to the olfactory receptor Or47a, the channel formed by Or47a and co-receptor Orco ...

Scientists have discovered that T cell receptors activate through a hidden spring-like motion that had never been seen before. This breakthrough may help explain why immunotherapy works for some ...

Chimeric antigen receptor-T (CAR-T) cell therapy represents a major breakthrough in cancer immunotherapy, providing remarkable clinical benefits for ...

A bitter taste receptor, TAS2R14, has been shown to respond to both extracellular and intracellular signals. Indeed, it can respond to both signals simultaneously. This finding is especially ...

Phase II Trial of Nivolumab Plus Doxorubicin, Vinblastine, Dacarbazine as Frontline Therapy in Older Adults With Hodgkin Lymphoma Colorectal cancer (CRC) remains a major global health burden, being ...

Coronaviruses have found another door into human cells, and it is one that scientists were not watching. A bat virus isolated ...