This is the game the 49ers have had circled on their calendar since the moment the schedule dropped. This is their shot for revenge. This is their chance to prove that they are, in fact, still the top dogs in the NFC West and,

The 49ers have yet to allow a sack in 2026, but NFL.com predicts a Seahawks sack party for Brock Purdy and San Francisco's first loss of the season.

Here are some NFL trades available at Kalshi and Polymarket for Sunday's Week 4 matchup between Denver and San Francisco

David Fucillo makes picks for all 16 NFL games with levels of confidence ahead of Week 5. Sam Farmer makes his picks and predictions for Week 5 of the NFL season, with the 49ers prevailing over the Seahawks and the Rams beating the Bills.

The Denver Broncos (2-1) head to Levi’s Stadium on Sunday to take on the unbeaten San Francisco 49ers (3-0) in one of Week 4’s marquee matchups. Denver has knocked off the Jaguars and the Rams the last two weeks after a Week 1 loss in Kansas City,

Five things to watch and a prediction for the showdown between the Packers and Bears in Week 5.

My Broncos vs. 49ers best bet is Denver to cover the spread (+3), with the best price currently available at DraftKings. Make sure to find the best odds by checking our live NFL odds page. Download the Action Network app now for more NFL picks and analysis!

Taking a look at who the NFL experts are taking in the Week 5 matchup between the Tennessee Titans and Houston Texans.